Overview
Remediation of Age-related Cognitive Decline: Vortioxetine and Cognitive Training
Status:
Completed
Completed
Trial end date:
2019-01-24
2019-01-24
Target enrollment:
0
0
Participant gender:
All
All
Summary
The purpose of this research study is to examine the potential benefits of vortioxetine in combination with at-home computerized cognitive training program to improve cognition, such as memory, attention, and concentration. This study will compare the effectiveness of vortioxetine plus cognitive training versus placebo plus cognitive training.Phase:
Phase 4Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Washington University School of MedicineCollaborators:
Queen's University
TakedaTreatments:
Vortioxetine
Criteria
Inclusion Criteria:- Community-living men and women age 65 and older
- Age-related cognitive decline as defined by (a) self-reported cognitive dysfunction
that is attributed to the aging process (in response to screening questions to the
participant); (b) ability to complete cognitive battery, but still scoring less than 1
standard deviation above age-matched norms at both baseline and after the two-week
cognitive training lead-in.
Exclusion Criteria:
- Known dementia or other clinical neurodegenerative illness (e.g., Parkinson's disease,
cerebrovascular disease) per self-report, informant report, medical records, or
neuropsychological testing
- Any current psychiatric disorder
- Medical conditions that suggest shortened lifespan, such as metastatic cancer; or
would prohibit safe participation in the interventions, including cardiovascular
disease or musculoskeletal conditions; or with the assessments.
- Sensory impairment that would prevent participation
- IQ < 70 as estimated by the Wechsler Test of Adult Reading
- Alcohol or substance abuse within 6 months
- Concurrent cognitive training, such as brain-training software, or other interventions
expected to affect neuroplasticity
- Psychotropic medications or those with likely CNS effects (none within 4 weeks prior
to study entry)