Relmacabtagene Autoleucel as First-Line Therapy for High-Risk Large B-Cell Lymphoma

• Status: Not yet recruiting
• Trial end date: 2024-12-10
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective of this study is to estimate the efficacy of Relmacabtagene Autoleucel in participants with high-risk large B-cell lymphoma.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University Cancer Hospital & Institute
• Collaborator: Shanghai Ming Ju Biotechnology Co., Ltd.
• Treatments: Cyclophosphamide; Fludarabine

Criteria

Inclusion Criteria:

1. ≥ 18 years old;

2. Sign on the informed consent;

3. Histologically confirmed large B-cell lymphoma that also meets the definition of high-risk large B-cell lymphoma as a lymphoma International Prognostic Index (IPI) score of 3-5 and/or high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangement (double/triple-hit lymphoma) (DHL/THL) and must be treated with 2 cycles of CD20 monoclonal antibodies combined with anthracyclines. Presence of positive PET assessable lesions (DS score of 4 or 5) as determined by the Lugano criteria (Cheson et al., 2014)；

4. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1;

5. Expected survival greater than 12 weeks；

6. Adequate organ function：

1. Absolute neutrophil count ≥ 1000/μL；Absolute lymphocyte count ≥ 100/μL； Platelet count ≥ 75,000/μL；Hb ≥ 80g/L；

2. Serum creatinine ≤ 1.5 × upper limit of normal (ULN) or creatinine clearance (Cockcroft-Gault formula) > 50 mL/min (serum creatinine clearance due to lymphoma mass compression should be > 30 mL/min)；

3. Serum alanine aminotransferase (ALT) ≤ 5 upper limit of normal (ULN) and total bilirubin ≤2ULN（or for subjects with Gilbert's syndrome or lymphoma invading the liver < 3 ULN）；

4. Baseline oxygen saturation > 92% on room air；

5. Left ventricular ejection fraction (LVEF) ≥50% assessed by echocardiography or radionuclide activity angiography (MUGA) within 1 month of enrollment；

7. Adequate vascular access for leukapheresis procedure;

8. Women of childbearing potential must agree to use highly effective methods of contraception for at least 28 days prior to lymphocyte clearance chemotherapy through 1 year after Relmacabtagene Autoleucel infusion; Males who have partners of childbearing potential must agree to use an effective barrier contraceptive method for 1 year after Relmacabtagene Autoleucel infusion.

Exclusion Criteria:

1. Lymphoma involving the central nervous system (CNS)；

2. History of another primary malignancy that has not been in remission for at least 2 years;

3. History of Richter's transformation of chronic lymphocytic leukemia or primary mediastinal B-cell lymphoma；

4. Subjects has HBV, HCV, HIV or syphilis infection at the time of screening;

5. Deep venous thrombosis (DVT)/Pulmonary embolism (PE), or DVT/PE requires anti-coagulation within 3 months prior to signing the ICF;

6. Subjects with uncontrolled systemic fungal, bacterial, viral or other infection;

7. Presence of acute or chronic graft-versus-host disease (GVHD);

8. History of any serious cardiovascular disease or presence of clinically relevant CNS pathology;

9. Pregnant or nursing women;

10. Subjects Received an autologous or allogeneic hematopoietic stem cell transplant；

11. Uncontrolled conditions or unwillingness or inability to follow the procedures required in the protocol;

12. Received CAR T-cell or other genetically-modified T-cell therapy previously；

13. Received live vaccination within 6 weeks prior to lymphocyte clearance chemotherapy；

14. History of severe hypersensitivity reactions to any of the drug ingredients used in this study product.