Release of Osteogenic Markers in Immediately and Non-loaded Dental Implants

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study was to compare the release of the osteoprotegerin (OPG), transforming growth factors (TGF-α), osteocalcin (OCN), osteopontin (OPN), and parathyroid hormone (PTH) during osseointegration of dental implants with and without immediate loading. Forty patients were selected and randomly divided into: Group IM - implant and prosthesis placement within 72 hours; and Group NL - implant insertion and no prosthesis placement during 120 days. Peri-implant crevicular fluid (PICF) was collected immediately after implant insertion and with 7, 15, 30, 60, 90, and 120 days after surgery and were evaluated levels of OPG, TGF-α, OCN, OPN and PTH using Luminex assay. Clinical aspects (Sulcus bleeding and peri-implant probing depth) were also assessed. The data were compared using the ANOVA/Tukey and Friedman/Mann-Whitney tests (α=5%).

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Renato Correa Viana Casarin

Criteria

Inclusion Criteria:

• patients with mandibular and/or maxillary edentulous arch indicated for rehabilitation with dental implants

• extractions had to occur at least 4 months prior to treatment

• good oral hygiene (plaque index < 20%) (Ainamo & Bay, 1975)

• age between 18-65 years

Exclusion Criteria:

• presence of systemic disease (including diabetes, arthritis, hypothyroidism, osteoporosis, etc) or use of medication (six months prior to the study) that contraindicated placement or alter implants osseointegration

• use of anti-inflammatory three months before surgery

• patients submitted to bone grafts in the site selected for the implant

• pregnant or breastfeeding women

• smokers or ex-smokers