Relative Bioavailability Study in Healthy Subjects
Status:
Completed
Trial end date:
2009-07-09
Target enrollment:
Participant gender:
Summary
Part 1 of this study will assess the relative bioavailability of GSK1322322 administered as
one of three investigational tablets compared to powder in a bottle formulation.
Pharmacokinetics of these three tablets will be evaluated and the investigation tablet with
the optimal PK profile will be progressed to Part 2. In Part 2 the investigational tablet
selected from Part 1 will be coadministered with food alone, an H2 blocker alone, or an H2
blocker given in combination with ascorbic acid to evaluate the effect on GSK1322322
pharmacokinetics. Plasma GSK1322322 PK profile, safety, and tolerability will be assessed
from each dose group.