Relationship Between Serum Vitamin D Levels and Musculoskeletal Adverse Effects in Patients Using Isotretinoin

• Status: Completed
• Trial end date: 2019-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Isotretinoin (ISO) has been used in the treatment of patients with severe acne vulgaris (AV) that is resistant to standard therapy with systemic antibiotics and topical agents, over the last few decades. There are various side effects of ISO in the skeletal system.

This study investigate the relationship between ISO-induced musculoskeletal adverse effects and serum 25 hydroxy (OH) vitamin D levels in patients with acne vulgaris.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ankara Training and Research Hospital
• Treatments: Isotretinoin; Vitamin D

Criteria

Inclusion Criteria:

• ISO at a dose of 0.5-1 mg/kg/day for at least 3 months,

• not to use vitamin D and/or calcium supplements for the last three months

• to be older than 18 years.

Exclusion Criteria:

• Patients who had renal, gastroenteritis, skeletal, psychiatric, hematological, endocrine disorders related with thyroid and bone metabolism

• Patients receiving drugs such as diuretics, multivitamins, anticonvulsants, glucocorticoids, erythromycin, estrogen compound pills, alcohol, vitamin D and/or calcium preparats in the last three months,

• Malignancy,

• Chronic liver and kidney failure,

• History of psoralen and ultraviolet A (PUVA)

• Women waiting pregnancy.