Reinitiation of Anticoagulation After Temporary Withdrawal of Vitamin K Antagonist
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
It is not known how to best restart warfarin after temporary withdrawal. Participants will be
randomized to two groups. Group 1 will restart warfarin at their usual maintenance dose,
group 2 will restart warfarin at double their maintenance dose for two days followed by their
usual maintenance dose. The main outcome parameter will be the number of patients who are
back in therapeutic INR (international normalized ratio) range 4, and 9 days after restarting
anticoagulation with warfarin. Thromboembolic and/or bleeding events will be recorded as
additional parameters. These data will be collected by a standardized telephone interview at
1 month. In addition, the investigators will evaluate a possible prothrombotic state by
measuring the potential of thrombin generation and D-dimers in the subset of patients
visiting HHS-General Hospital for their INR tests.