Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development

• Status: Completed
• Trial end date: 2020-01-01
• Target enrollment: 0
• Participant gender: Male

Summary

To investigate the role of ATP sensitive K+ potassium channels and the Na+/K+ pump in the development of fatigue in healthy and in pre/diabetic subjects.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Copenhagen
• Treatments: Glimepiride; Nicorandil

Criteria

Inclusion Criteria:

• Non smokers

• HbA1c <38mmol/mol and >42 mmol/mol

• VO2max <40 ml/kg/min

• BMI >26 kg/m2

Exclusion Criteria:

• Use of antidiabetic medication

• Allergy towards Nicorandil of Glimepiride

• Chronic disease other than type 2 diabetes