Regulation of Insulin Secretion by the GLP-1 Receptor
Status:
Recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
AIM2: The purpose of Aim-2 of this study is to determine the role of basal GLP-1 action on
the beta-cell response to insulin resistance. Healthy subjects will have fasting GLP-1 action
determined with GLP-1r blockade before and after induction of experimental insulin
resistance. The investigators hypothesize that fasting GLP-1 action will increase to
compensate for experimental insulin resistance.
AIM3: The purpose of Aim-3 of this study is to determine the role of basal GLP-1 action on
fasting glucose regulation in lean, obese, pre-diabetic and type 2 diabetic (T2DM) subjects.
A cross sectional study of age-matched subjects across the spectrum of glucose tolerance will
be used to test the hypothesis that fasting GLP-1 action increases as beta-cell function
declines.
Phase:
Phase 4
Details
Lead Sponsor:
David D'Alessio, M.D. VA Office of Research and Development