Regulation of Endogenous Glucose Production by Brain Insulin Action
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
It is well known that the hormone insulin lowers blood glucose in part by acting directly on
the liver and reducing hepatic glucose production. Animal studies have shown that the hormone
insulin can act on the brain to indirectly lower glucose production by the liver. We aim to
test whether this is true in humans by giving insulin intranasally. It has previously been
shown that a nasal spray can deliver insulin directly to the brain without affecting
circulating insulin concentration.