Overview

Regulation of Cervical Mucus Secretion

Status:
Completed
Trial end date:
2017-08-23
Target enrollment:
Participant gender:
Summary
The purpose of this study is to help us determine how hormones impact the production of cervical mucus which is a fluid secreted by the opening of the uterus, also called the cervix. During a normal menstrual cycle, cervical mucus changes in response to two hormones that the ovaries make: estrogen and progesterone. Many of the birth control methods women use thicken mucus and make it less likely for sperm to enter the uterus. The goal of this study is to better understand the effects estrogen and progesterone have on the cervical mucus in the body. To do this, the investigators will be using a drug that suppresses natural hormone production for 3 months. Estrogen and progesterone will be artificially replaced to better understand their effects. The investigators will also be studying the effect of a common birth control pill that may work by thickening cervical mucus. Last, the investigators will study some of the cells in the cervix that produce mucus.
Phase:
Phase 4
Details
Lead Sponsor:
Oregon Health and Science University
Collaborator:
Society of Family Planning
Treatments:
Estradiol
Estradiol 17 beta-cypionate
Estradiol 3-benzoate
Estradiol valerate
Estrogens
Leuprolide
Norethindrone
Norethindrone acetate
Polyestradiol phosphate
Progesterone
Progestins