Regional Anesthesia in Colon Rectal Surgery

• Status: Withdrawn
• Trial end date: 2013-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will compare recurrence rates in patients with colorectal cancer who will be randomly assigned to epidural anesthesia/analgesia combined with general anesthesia or to general anesthesia followed by opioid analgesia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Cleveland Clinic
• Treatments: Analgesics, Opioid; Anesthetics

Criteria

Inclusion Criteria:

• Primary colon cancer without known extension beyond colon (T3, N0, M0)

• Scheduled for open, laparoscopic assisted and laparoscopic resection of the colon.

• Written informed consent, including willingness to be randomized to epidural anesthesia/analgesia or to sevoflurane general anesthesia and postoperative opioid analgesia.

Exclusion Criteria:

• Previous surgery for colon cancer;

• Any contraindication to epidural anesthesia or analgesia (including coagulopathy, abnormal anatomy);

• Any contraindication to midazolam, propofol, sevoflurane, fentanyl, or morphine;

• Age <18 or >85 years old;

• ASA Physical Status ≥4;

• Other cancer not believed by the attending surgeon to be in long-term remission;

• Systemic disease believed by the attending surgeon or anesthesiologist to present ≥25% two-year mortality.