Regenerative Treatment of Traumatized Immature Permanent Incisors With Pulp Necrosis
Status:
Recruiting
Trial end date:
2023-12-19
Target enrollment:
Participant gender:
Summary
Endodontic management of traumatized immature permanent teeth with pulp necrosis is both a
clinical challenge for the dental practitioners and a public health care problem. Even though
there are feasible treatment procedures (such as apexification with calcium hydroxide and
with Mineral Trioxide Aggregate (MTA), the long-term survival of these teeth is questionable
because none of these techniques can provide continuation of root formation and thickening of
the dentin walls. As a result, the immature tooth is weak and prone to fracture.
Recently, regenerative endodontic procedures have gained much attention as biologically based
treatment alternative to the techniques described above, but the scientific evidence is
insufficient. These procedures aim to remove necrotic and damaged tissues and replace those
with healthy functioning pulp-dentin complex.
We plan to invite 120 patients to participate in this study. The inclusion criteria will be
children between the ages of 7-19 years with traumatized permanent incisors with immature
roots and open apices and pulp necrosis. Patients will be recruited from specialist clinics
in Stockholm, Västerbotten and Norrbotten. The patients will be treated by specialists in
endodontics and pediatric dentistry with regenerative endodontics. During a 5-year follow-up
period the most important outcomes are continuous root development and healing of pulp
necrosis. Severe traumatic dental injuries leading to severe complication that could result
in early tooth loss can have a severe impact on oral health related quality of life.
Therefore, regenerative endodontics can have beneficial effect treating these teeth.
Phase:
N/A
Details
Lead Sponsor:
Karolinska Institutet
Collaborators:
Eastman Dental Insitute and Hospital Eastmaninstitutet, Depertment of Endodontics and Department of Pediatric Dentistry Umeå University Umeå University, Department of Endodontics