Reduction of Night-time Blood Pressure in Pediatric Renal Transplant Recipients
Status:
Completed
Trial end date:
2020-08-01
Target enrollment:
Participant gender:
Summary
The proposed study investigated the effect of chronotherapeutic alteration of
anti-hypertensive medication on nocturnal hypertension and end-organ injury in pediatric
renal transplant recipients who are non-dippers. Additionally, the investigators examined the
association between response to intervention, serum adiponectin levels and adiponectin gene
polymorphisms. The investigators hypothesized that (1) evening administration of
anti-hypertensive medication will convert subjects from non-dipper to dipper status, improve
mean nocturnal blood pressure (BP), and improve nocturnal BP load, (2) evening administration
of anti-hypertensive medication will reduce albuminuria, left ventricular mass index (LVMI),
rate of decline of glomerular filtration rate (eGFR) and will decrease pulse wave velocity
(PWV).