Reduction of Cesareans by Nitric Oxide (NO) Donors in Post Term Pregnancies

• Status: Completed
• Trial end date: 2014-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this trial is to determine whether cervical ripening with isosorbide mononitrate reduce caesarean section in women with post term pregnancies.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Isosorbide-5-mononitrate

Criteria

Inclusion criteria :

• Age > or = 18 years old

• TAS > or = 95 mmHg

• Singleton

• Nulliparity

• Term > or = 41 weeks + 0 day

• Bishop score < or = 5

• Vertex presentation

• Intact membranes

• No contra-indications of the study treatment

• No maternal or fetal diseases which could indicate immediate labor induction

• Written informed consent

Exclusion criteria :

• Multiple pregnancy

• Multiparity

• Term < 41 weeks

• Bishop score > 5

• Breech presentation

• Rupture of the membranes

• Previous cesarean

• Indication to immediate labor induction

• Contraindications to isosorbide mononitrate

• No co-administration of antihypertensive drugs

• No social security