Reducing the Burden of Malaria by Targeting Hotspots of Malaria Transmission
Status:
Completed
Trial end date:
2012-11-01
Target enrollment:
Participant gender:
Summary
In this study, the investigators propose to determine the value of rolling out four targeted
malaria control efforts in reducing overall malaria transmission. These targeted control
efforts include local upscaling of IRS and ITNs in hotspots of malaria transmission. In
addition, larviciding will be employed to target malaria vectors, also those that are less
susceptible to IRS and ITNs as a consequence of outdoor feeding and resting. Lastly, the
human infectious reservoir will be reduced in hotspots of malaria transmission by treating
parasite carriers and their household members with the current first-line antimalarial drug.
The impact of these targeted interventions on overall transmission intensity will be assessed
in the context of currently ongoing malaria control activities in a plausibility study.
Hotspots of malaria transmission are defined in an area of 100km2 and randomized to receive
hotspot targeted interventions and compared with their baseline and with control clusters
where the routine (untargeted) malaria control activities continue. The interventions will be
evaluated based on changes in parasite prevalence measured in community surveys inside and
outside hotspots of malaria transmission. Parasite prevalence will be compared before and
after the intervention in intervention clusters and between intervention and control
clusters.
In addition to malaria surveys in the human population, an entomological evaluation will take
place where the densities of mosquito larvae and adult mosquitoes are monitored
longitudinally.
Phase:
N/A
Details
Lead Sponsor:
Radboud University
Collaborators:
Centers for Disease Control and Prevention Division of Malaria Control, Ministry of Health, Nairobi, Kenya International Centre of Insect Physiology and Ecology (ICIPE) Kenya Medical Research Institute Kenya Medical Research Institute, Kisumu, Kenya London School of Hygiene & Tropical Medicine, London, UK
Treatments:
Artemether Artemether-lumefantrine combination Artemether, Lumefantrine Drug Combination Artemisinins Lumefantrine