Overview

Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

Status:
Not yet recruiting

Trial end date:
2029-03-01

Target enrollment:

Participant gender:

Summary

This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outcomes over a 12 month period and test the hypothesis that a potent antioxidant intervention (glycine + N-acetyl-cysteine(GlyNAC)) reduces oxidative stress and chronic post surgical pain (CPSP) in patients undergoing total knee arthroplasty (TKA).

Phase:

Phase 4

Details

Lead Sponsor:

Vanderbilt University Medical Center

Collaborator:

National Institute on Aging (NIA)

Treatments:

Acetylcysteine
Glycine
N-monoacetylcystine