Reducing Nephrotoxicity of Vancomycin: A Prospective Study of Continuous Versus Intermittent Infusion of Vancomycin

• Status: Unknown status
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is being carried out to find out whether there is reduction in vancomycin-induced kidney injury (nephrotoxicity) when vancomycin is given as intermittent versus continuous infusion.

This study will recruit 220 subjects from 2 hospitals over a period of 3 years.

Participants are invited if they have an infection that requires prolonged vancomycin therapy (> more than 10 days).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National University Hospital, Singapore
• Collaborator: Tan Tock Seng Hospital
• Treatments: Vancomycin

Criteria

Inclusion Criteria:

• Adults aged 21-80 years

• Documented infection requiring prolonged (> 10 days) of vancomycin therapy

• Creatinine clearance > 50 ml/min (using Cockroft-Gault equation)

Exclusion Criteria:

• Patient already received 7 days or more of vancomycin therapy

• Pregnancy

• Severe burns > 40% body surface area

• Spinal cord injuries

• Participation in another interventional trial in previous 30 days

• Inability to obtain informed consent