Reducing Exercise-induced Bronchoconstriction in Children With Asthma and Obesity
Status:
Terminated
Trial end date:
2021-03-30
Target enrollment:
Participant gender:
Summary
Guidelines from the American Thoracic Society strongly recommend interval warm-up exercise
before planned exercise to reduce exercise-induced bronchoconstriction severity. However, no
empirical data on the effects of interval warm-up exercise on exercise-induced
bronchoconstriction severity are available in obese asthmatic children, where excess fat
exerts such an unfavorable burden on the respiratory system, particularly during exercise.
The objective of this study is to investigate the effects of interval warm-up exercise on
exercise-induced bronchoconstriction severity in obese and nonobese asthmatic children. Our
approach will be to investigate exercise tolerance, respiratory function, and
exercise-induced bronchoconstriction severity and the effects of (1) 8x30sec interval warm-up
& (2) pretreatment with a bronchodilator compared with a no-treatment control on
exercise-induced bronchoconstriction severity in 8-12 yr, prepubescent, obese and nonobese
asthmatic children.
[Aim]: To investigate the effects of interval warm-up exercise on exercise-induced
bronchoconstriction severity. [Hypothesis]: Interval warm-up exercise will reduce
exercise-induced bronchoconstriction severity after an exercise challenge test to a similar
extent as bronchodilator and better than control.