Reducing Blood Loss During Cesarean Section by Topical Versus IV Tranexamic Acid
Status:
Completed
Trial end date:
2020-08-01
Target enrollment:
Participant gender:
Summary
Tranexamic (TXA)acid is an inexpensive, antifibrinolytic drug long used to control bleeding
due to surgery, menorrhagia, or trauma. Additionally, tranexamic acid has been shown to
reduce bleeding during cesarean delivery as well as the need for additional uterotonic
agents, albeit to a minimal degree. However, previous studies have been performed only in
women with a standard risk for postpartum hemorrhage( PPH) and have not focused on assessing
the effects of tranexamic acid in high-risk women. The aim of this study is to evaluate the
efficacy of IV versus topical application of tranexamic acid in reducing blood loss during
and after elective C.S. The Research Question Is topical application of Tranexamic acid
effective in reducing blood loss during and after an elective Caesarean section? The Research
Hypothesis the TXA could be able to reduce blood loss during and after elective Caesarean
section. The null hypothesis will, therefore, state that: There will be no difference between
topical and IV TXA and placebo in reducing blood loss during and after elective Caesarean
section.