Reduced Nicotine Cigarettes in Smokers With Mood and Anxiety Disorders
Status:
Completed
Trial end date:
2018-03-23
Target enrollment:
Participant gender:
Summary
The overall aim of this project is to evaluate the effect of progressive nicotine reduction
in cigarettes on smoking behavior, toxin exposure and psychiatric symptoms in smokers with
comorbid mood and/or anxiety disorders.
Smokers with mood and/or anxiety disorder will smoke research cigarettes that will contain
either a) nicotine content similar to their preferred usual brand of cigarettes, or b)
nicotine content per cigarette that is progressively reduced from approximately 11.6 mg to
0.2 mg per cigarette over 18 weeks.
It is our hypothesis that nicotine intake will decline as a function of cigarette nicotine
content in the Reduced Nicotine Content group without significant increases in tobacco smoke
exposure, severity of nicotine withdrawal symptoms, mood and anxiety symptomatology or
protocol non-adherence over time in the Reduced Nicotine Content group as compared with the
control group.