Reduced Intensity AlloTransplant For Osteopetrosis
Status:
Terminated
Trial end date:
2008-05-01
Target enrollment:
Participant gender:
Summary
We believe that hematopoietic stem cell transplantation (HSCT) will help subjects with
Osteopetrosis generate functioning osteoclasts, and by so doing assist in the resolution of
the abnormal bone architecture, and the anemia and bone marrow failure that is also
characteristic of this disease. However, we have found in past studies that approximately 30%
of Osteopetrosis patients do not engraft. Therefore, in this study, we plan to use a
different combination of pre-transplant drugs to try to make transplants safer for this
disease, as well as to provide a second infusion of stem cells in patients with matched
related or unrelated donors. The purpose of this research is to find a safer and more
effective means of performing stem cell transplantation in patients with Osteopetrosis, using
chemotherapy and radiation designed to bring about engraftment and lessen transplant
mortality.