Recovery Profiles of Remifentanil-based Regimen for Cardiac Surgery
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Backgrounds: Monitoring of Bispectral index (BIS) has been regarded as useful to determine
the degree of intraoperative hypnosis. Major factors of postoperative recovery after cardiac
surgery include patient's recovery in cognitive function from the postoperative residual
effects of anesthetics, such as opioids and sedatives, administered during intraoperative
period. Therefore employing anesthetic regimens which can provide earlier recovery in
cognitive function would be beneficial in facilitating fast-track cardiac surgery with
earlier postoperative extubation and discharge from the intensive care unit (ICU).
Previous investigations suggested efficacy of BIS in evaluating the degree of postoperative
hypnosis in the ICU.
The present study compares the time for reaching BIS greater than 80 after using 2 different
anesthesia regimens for cardiac surgery, remifentanil-based regimen and
sevoflurane-sufentanil balanced regimen.
Analyzing the changes immediately after cardiac surgery would be useful to determine the
degree of patient's postoperative emergence.
Materials and Methods:
During study period, patients undergoing elective cardiac surgery in Konkuk University
Medical Center are randomly assigned to get remifentanil-based regimen consisting of
remifentanil 0.75 mcg/kg/min and supplemental propofol for maintaining BIS 40-60 (Group R) or
sevoflurane (end-tidal 1.2-2.8 vol%) and sufentanil (0.015 mcg/kg/min) balanced regimen in
Group S.
All patients get intravenous patient controlled anesthesia consisting of alfentanyl and
ondansetron after surgery. Supplemental remifentanil 0.25-0.3 mcg/kg/min is administered
during postoperative 2 hours in Group R.
As a primary objective, inter-group difference in the time for achieving BIS greater than 80
is determined.