Recombinant Human Leptin Therapy Effects on Insulin Action
Status:
Completed
Trial end date:
2000-07-01
Target enrollment:
Participant gender:
Summary
Leptin therapy improves insulin sensitivity in people with leptin-deficiency but it is not
known whether it improves insulin action in persons who are not leptin deficient. The purpose
of the present study was to determine whether leptin therapy has effects on insulin action in
obese subjects with type 2 diabetes mellitus (T2DM). A randomized, placebo controlled trial
was conducted in obese subjects with newly-diagnosed T2DM. Subjects were randomized to
treatment with placebo, low-dose, or high-dose leptin. Insulin sensitivity was measured.