Real Time Myocardial Perfusion Echocardiography for Coronary Allograft Vasculopathy

• Status: Completed
• Trial end date: 2018-06-30
• Target enrollment: 0
• Participant gender: All

Summary

Is real-time myocardial perfusion echocardiography (RTMPE) a feasible and effective non-invasive method to detect significant Coronary Allograft Vasculopathy in pediatric and adult cardiac transplant recipients? Will perfusion deficits correlate with significant coronary artery stenosis identified by standard stress echocardiography and Invasive Coronary Angiography (ICA), and identify diffuse small vessel disease more effectively than current non-invasive techniques?

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Collaborator: University of Calgary

Criteria

Inclusion:

• Cardiac transplant recipients (> or equal to 10 months post transplant)

• Clinically followed at Mayo Clinic, Rochester Minnesota

Exclusion:

• Standard contraindications to the use of ultrasound contrast and pharmacologic stress

• Recent (< 3 months) hospitalization for heart failure, acute coronary syndrome or allograft rejection

• Multi-organ transplant Known or suspected right-to-left, bi-directional, or transient right-to-left cardiac shunts

• Hypersensitivity to perflutren