Re-exposure of Human Volunteers to a Heterologous Strain of P. Falciparum Sporozoites
Status:
Completed
Trial end date:
2013-01-01
Target enrollment:
Participant gender:
Summary
In a previous study (NL33904.091.10) the investigators challenged 24 volunteers after
Chloroquine Prophylaxis Sporozoites (CPS) immunization with 45, 30 or 15 infected
mosquito-bites respectively. The availability of this immunized cohort opens the unique
opportunity to determine protection to a heterologous challenge for both of the protected and
unprotected volunteers as the previous challenge infection might have served as immunological
boost to the unprotected volunteers.
In the current observational, proof of principle study, the investigators aim to investigate
the protection on an individual basis of these previously immunized and challenged volunteers
against a heterologous P. falciparum challenge.