Re-STOP DVT: Reload of High Dose Atorvastatin for Preventing Deep Vein Thrombosis in Statin Users
Status:
Unknown status
Trial end date:
2012-03-01
Target enrollment:
Participant gender:
Summary
Reload of high dose statin may have potential for preventing deep vein thrombosis (DVT) in
patients on statin undergoing total knee replacement arthroplasty.
A body of evidence have been reported that reloading of atorvastatin have efficacy in
reducing periprocedural myocardial infarction and contrast induced nephropathy. These effects
are considered to be mainly due to their antioxidant anti-thrombotic and anti-inflammatory
property.
We, therefore, hypothesize that high dose atorvastatin re-loading may prevent DVT.