Rapid Versus Prolonged Inpatient Up-Titration of Captopril

• Status: Unknown status
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective of this study is to establish a safe and effective method of up-titration of captopril for hospital inpatients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Hospital for Sick Children
• Treatments: Captopril

Criteria

Inclusion Criteria:

• Pediatric cardiology in-patients at The Hospital for Sick Children

• Primary physician has decided to commence ACEi (the division has agreed that our institutional choice will be to start patients on captopril and up-titrate to optimal dose before converting to other ACEi)

• Patients who have been initiated on captopril within the prior 24 hours, but have not yet started up-titration, will be eligible to be randomized

Exclusion Criteria:

• Known sensitivity to ACEi

• Infants on the neonatal intensive care unit

• Treatment with any ACEi for more than 24 hours within the preceding 6 months

• Age > 18 years