Rapid Infusion Rituximab, Hematologic, Oncologic, and Rheumatologic Disorders
Status:
Completed
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
Rituximab is frequently used in adult and pediatric cancers, blood disorders, lymphoma (a
cancerous growth made up of lymphoid tissue), graft-versus-host-disease (complication that
can occur after a stem cell or bone marrow transplant), diseases of the immune system (the
cells and substances that protect the body from infection) and rheumatologic conditions.
Rituximab works by decreasing or temporarily eliminating a specific type of white blood cell,
the B-lymphocyte. Overall, rituximab is generally well tolerated. The likelihood of an
infusion-related reaction, or symptoms such as fever, chills, hives, low blood pressure or
swelling, is very low, but highest during a patient's first infusion of rituximab and
decreases with each additional dose. Adults commonly receive rituximab at a faster rate if
they have done well with the first infusion, this study will help determine if the same
approach is well tolerated in children.
In this study, the investigators are testing a new method of administering rituximab which
may reduce the time it takes to receive the medication. The initial ordered amount of
rituximab will not change from the current standard of care (meaning what is usually done by
doctors, and would likely be done if you were not on this study). The period of time over
which rituximab is given is what is being studied.