Rapid Effects of Hydrocortisone on Glucose-induced Insulin Secretion in Healthy Humans

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to investigate the effect of hydrocortisone on glucose-induced insulin secretion and sensitivity, by means of an intravenous glucose tolerance test with frequent sampling (FSIGT) followed by minimal model analysis. In a randomized single-blind cross-over design, the subjects will receive either hydrocortisone or placebo 4 minutes before an intravenous glucose load.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Medical University of Vienna
• Treatments: Cortisol succinate; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate

Criteria

Inclusion Criteria:

• Healthy subjects

• No concomitant medication

• BMI < 25 kg/m2

• Age: 18-60 years old

Exclusion Criteria:

• Impaired glucose tolerance or diabetes mellitus

• Hyperthyroidism, hypothyroidism

• Hepatic, renal or cardiovascular diseases

• Malignancies

• History of medical therapy within 3 weeks prior to enrolment into the study