The purpose of this study is to test whether a saline nebulization (breathing in a mist of
moist air through a mask) will help an individual cough up a better sputum sample to test for
tuberculosis (TB). In addition, this study will test whether samples obtained with saline
nebulization are better at finding TB in people with HIV infection. The study will enroll up
to 600 individuals, aged 12 and older, with suspected pulmonary TB. Participants will be
asked to cough up a sample of sputum into a container. Then, participants will be asked to
breathe a mist of moist air from an oxygen mask followed by moist salty air, which will help
individuals to cough up a second sputum sample. This mist of moist air will contain
salbutamol, a medicine to help open up the airways. The sputum samples will be sent to a
laboratory to test for TB. Additionally, participants will be tested for HIV with a blood
sample collection. Participants will be involved in study related procedures for up to 61
days.
Phase:
N/A
Details
Lead Sponsor:
University of Cape Town
Collaborator:
National Institute of Allergy and Infectious Diseases (NIAID)