Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses
Status:
Recruiting
Trial end date:
2025-03-31
Target enrollment:
Participant gender:
Summary
The central goal of this application is to demonstrate the causal contribution of reward
learning signals (expected values and reward prediction errors [RPE]) to antidepressant
responses (Aim1) by experimentally manipulating expected values using transcranial magnetic
stimulation (TMS) targeting the vmPFC (Aim 2) and μ-opioid striatal RPE signal using
pharmacological approaches (Aim 3).