Patients with ischemic heart disease often report multiple symptoms, including angina and
palpitations. Ranolazine has antiarrhythmic effects which are largely a result of the drug's
effect on multiple ion channels. It remains unknown, however, whether the favorable effects
of ranolazine on symptoms and arrhythmias are maintained over time. Aim of this study is to
test the hypothesis that chronic treatment with ranolazine can improve the symptomatic status
of patients with ischemic heart disease by reducing the occurrence of palpitations.