Overview

Randomized Trial of Veverimer on Muscle Mitochondrial Energetics and Physical Endurance in Persons With CKD

Status:
Not yet recruiting

Trial end date:
2026-07-30

Target enrollment:

Participant gender:

Summary

Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in vivo tools to study the pathophysiology of poor physical endurance in a clinical trial treating metabolic acidosis among persons living with chronic kidney disease.

Phase:

Phase 2

Details

Lead Sponsor:

University of California, Davis

Collaborator:

Vanderbilt University Medical Center