Randomized Trial of Two Antimalarial Treatments for Clearing Low Density P.Falciparum Parasitaemia in Sudan

• Status: Completed
• Trial end date: 2004-11-01
• Target enrollment: 0
• Participant gender: All

Summary

In areas of seasonal malaria transmission, treatment of carriers of malaria parasites, whose parasitaemia persists at very low levels throughout the dry season, could be a useful strategy for malaria control in areas with a short transmission season. We did a randomized trial to compare two regimens for clearance of low level parasitaemia in the dry season.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: London School of Hygiene and Tropical Medicine
• Collaborators: Tropical Medicine Research Institute; World Health Organization
• Treatments: Artemisinins; Artesunate; Fanasil, pyrimethamine drug combination; Primaquine; Pyrimethamine; Sulfadoxine

Criteria

Inclusion Criteria:

• infection with P.falciparum detected by PCR

Exclusion Criteria:

• pregnancy

• severe anaemia

• fever or other signs of illness

• history of allergy to sulfa drugs

• presence of other species of Plasmodium detected by microscopy