Randomized Trial of Sedative Choice for Intubation
Status:
Not yet recruiting
Trial end date:
2025-10-04
Target enrollment:
Participant gender:
Summary
Among critically ill adults undergoing emergency tracheal intubation, one in five experience
hypotension, cardiac arrest, or death. The sedatives used to rapidly induce anesthesia for
emergency tracheal intubation have been hypothesized to effect cardiovascular complications
and patient outcomes, but the optimal sedative medication for intubation of critically ill
adults remains unknown. Ketamine and etomidate are the two most commonly used sedatives
during intubation of critically ill adults. Data from a randomized clinical trial are
urgently needed to determine the effect of ketamine versus etomidate on cardiovascular
complications and clinical outcomes of emergency tracheal intubation.