Neurodevelopmental disability is now recognized as the most common long-term complication
after cardiac surgery in neonates. Research studies have shown that progesterone is critical
to the development of the brain and in a variety of clinical situations including brain
injury can protect the brain.
The purpose of this research study is to determine whether progesterone administered during
the 3rd trimester of pregnancy (24-39 weeks) to pregnant women protects the brain of unborn
babies with CHD and improves their neurodevelopmental outcomes after heart surgery.