Randomized Trial of Diphenhydramine Versus Continued Midazolam in "Difficult-to-sedate" Patients Undergoing Colonoscopy

• Status: Completed
• Trial end date: 2016-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients who are undergoing colonoscopy and are not adequately sedated after initial standard sedation with midazolam 5 mg and fentanyl 100 mcg will be randomly assigned to receive diphenhydramine vs. continued midazolam, and their level of sedation will be assessed. Our hypothesis is that diphenhydramine will provide better sedation than continued administration of midazolam during colonoscopy in patients not achieving adequate sedation with standard doses of midazolam plus fentanyl.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: VA Connecticut Healthcare System
• Treatments: Diphenhydramine; Midazolam; Promethazine

Criteria

Inclusion Criteria:

• Patients >18 years-old who are undergoing elective colonoscopy with conscious sedation

Exclusion Criteria:

• allergy or prior adverse reactions to diphenhydramine

• medical contraindications to use of diphenhydramine (e.g. closed angle glaucoma)

• pregnancy