Randomized Trial of Amoxicillin Versus Placebo for (Fast Breathing) Pneumonia
Status:
Completed
Trial end date:
2017-11-01
Target enrollment:
Participant gender:
Summary
The relative benefits and risks of antibiotic therapy in WHO defined fast breathing pneumonia
in pre-school children in resource limited settings are controversial both at an individual
and public health level. Most infections are viral or self-limiting and non-selective drug
treatment has contributed to the global epidemic of antibiotic resistance. There is no high
quality trial evidence in managing children with fast breathing in community settings and the
WHO itself has called for evidence on which to update guidance. The investigators proposed
non inferiority trial comparing standard antibiotic treatment with placebo in poor urban slum
settings in South Asia to address this deficit.