Randomized Study of Gonadotropin-releasing-hormone Agonist (GnRH-a) or Expectant Management for Endometriosis

• Status: Unknown status
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to identify the recurrent rate and pregnancy rate of advanced endometriosis after laparoscopic surgery plus GnRHa goserelin acetate treatment.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zhejiang University
• Treatments: Goserelin; Hormones; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Age >=18 years old

• Normal menstruation for 3 months before enrollment (25-35 days）

• Advanced endometriosis confirmed histologically (r-AFS score III-IV) with laparoscopy or laparotomy-pelvic pain and/or dysmenorrhea and/or dyspareunia

• Agreement on the strict follow-up plan

• Without previous hormonal treatment

• Using nonhormonal method of contraception during this study

Exclusion Criteria:

• Serious heart diseases/pulmonary/liver/kidney diseases

• Previous non-endometriosis relevant surgery possibly influence to abdominal or pelvic pain

• Suspected malignancy in endometriosis

• Coagulation disorders with hemorrhagic tendency

• Pregnancy or lactation

• Allergy to GnRHa

• Previous ineffective treatment with GnRHa