Randomized Study of Aspirin Resistant Patients Undergoing Angioplasty
Status:
Terminated
Trial end date:
2007-12-01
Target enrollment:
Participant gender:
Summary
This study is a randomized, double-blind, multi-center study designed to compare differences
in rates of myonecrosis (measured as an elevation of CK-MB ratio ≥ 2 times ULN) within 24
hours following low-medium risk percutaneous coronary intervention (PCI) in aspirin or
clopidogrel non-responsive patients who are randomized to heparin with or without
eptifibatide therapy during PCI. The primary objective of this study is to determine if the
use of eptifibatide is associated with a significant difference in post-PCI myonecrosis
(measured as an elevation of CK-MB ratio ≥ 2 times upper limit of normal [ULN]) within 24
hours of low-medium risk PCI in patients who are aspirin or non-responsive as determined by
VerifyNow Aspirin and P2Y12 testing.