Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache
Status:
Unknown status
Trial end date:
2008-10-01
Target enrollment:
Participant gender:
Summary
Headache during fasting is a known entity in the scientific literature. The prevalence of
such a headache is high and in a study conducted in Israel was found in 60% of people with a
previous predilection for headache. A prior study showed a significant decrease in the
incidence of fasting headache using rofecoxib, but the drug has been taken off the market.
The goal of this project is to evaluate the efficacy of etoricoxib as treatment taken before
the fast- a COX-2 inhibitor with a relatively long half life to prevent fasting induced
headache. The study will be a prospective double blind placebo controlled trial using adult
volunteers with a history of a fasting headache who will be abstaining from food and drink on
Yom Kippur.
The study hypothesis is that treatment with etoricoxib prior to a 25 hour fast will decrease
the incidence of fasting headache.