Randomized, Multicenter, Double-blind, Vancomycin-controlled Study to Evaluate the Efficacy of Ethanol Lock Solution for the Curative Treatment of Implantable Venous Access Port Infection Due to Coagulase-negative Staphylococci

• Status: Unknown status
• Trial end date: 2017-01-01

Summary

Implantable venous access port infections are mainly due to coagulase negative staphylococci and may be managed by antibiotic lock therapy with retention of the port. Most of the time a vancomycin lock is used. Experimental data show that vancomycin may be poorly effective in eradicating the staphylococcal biofilm in the port. Another disadvantage of Vancomycin-containing lock solution is the occurrence of resistant organisms and the risk of catheter occlusion. Ethanol-containing lock solution is highly effective in vitro and does not expose to the risk of emergence resistance.

• Phase: N/A

Details

• Lead Sponsor: University Hospital, Clermont-Ferrand
• Collaborators: Centre Jean Perrin; Centre Leon Berard; CH de Chambéry; CH Henri Mondor (Aurillac); CHG Jacques Lacarin (Vichy); Hôpital de la Croix-Rousse; Hôpital Nord (Saint-Etienne); Jacques Lacarin Hospital Center; University Hospital, Grenoble
• Treatments: Coagulase; Enoxaparin; Ethanol; Pharmaceutical Solutions; Vancomycin