Randomized, Double-Blind Cross-Over Trial Of Buprenorphine and Low-Dose Naloxone Versus Buprenorphine
Status:
Completed
Trial end date:
2009-11-01
Target enrollment:
Participant gender:
Summary
This study compares two medications for analgesic potency and side effects in a sample of
individuals with moderate pain. After screening, eligible participants will be randomly
assigned to begin blinded treatment with one of two medications. Participants receive 5 daily
doses of medication (no more than 2 days between each dose) followed by crossover to the
opposite treatment condition for 5 additional daily doses. Each study day, participants will
provide a daily pain assessment, receive administration of study medication, and will then be
monitored and assessed for pain and side effects over 6 hours.