Randomized Controlled Trial for Exparel Hip Fracture

• Status: Completed
• Trial end date: 2019-01-22
• Target enrollment: 0
• Participant gender: All

Summary

This is a prospective, randomized study looking at the effect that a long-acting local anesthetic has on pain control in patients having surgery for hip fractures. The investigators are conducting the study to see if that reduces the amount of pain medicine needed after surgery, and if it reduces other medical complications after surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Massachusetts, Worcester
• Collaborators: Orthopaedic Trauma Association; University of Kentucky
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

• Age 55 or older

• Sustaining either an OTA/AO type 31A or 31B fracture undergoing ORIF or hemiarthroplasty

• Able to consent

• Isolated injury

Exclusion Criteria:

• OTA/AO 31B1 (Impacted/slightly displaced)

• Baseline dementia or cognitive deficit

• Inability to consent

• Chronic Opioid use

• End stage liver disease with Model for End-Stage Liver Disease (MELD) greater than 20.

• End stage renal disease as defined by patients requiring hemodialysis at least twice weekly

• Polytrauma, defined as: concurrent upper or lower extremity fracture, pelvis fracture, spine fracture, rib fractures, or facial fractures, Blunt chest or abdominal trauma resulting in diagnosed organ injury, Head trauma resulting in intracranial bleed or diagnosed concussion

• Allergy to amide-type local anesthetics

• Prisoners (unlikely to be accessible for follow-up)