Randomized Clinical Trial of Enamel Matrix Derivative: Radiographic Analysis

• Status: Completed
• Trial end date: 2005-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a split-mouth, double-blind randomized controlled trial. Computerized linear radiographic measurements were used to detect infrabony defects treated with open flap debridement (OFD) or OFD associated with enamel matrix derivative (EMD), after 24 months. Ten patients presenting 2 or more defects were selected (43 defects). An individualized film holder was used to take standardized radiographs at baseline and after 24 months. Images were digitized and used to measure the distances from the cemento-enamel junction (CEJ) to the alveolar crest (AC), CEJ to the bottom of the defect (BD) and infrabony defect angle.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo

Criteria

Inclusion Criteria:

1. diagnosis of chronic periodontitis

2. presence of at least one pair of interproximal infrabony defects (2-3 walls) adjacent to vital anterior or premolar teeth

3. absence of 2 and 3 mobility degrees

4. probing pocket depth (PPD)≥ 5mm

5. full-mouth plaque score ≤ 20%

6. keratinized tissue width of at least 2mm

Exclusion Criteria:

1. presence of any systemic disease that could interfere with periodontal treatment

2. infrabony defects with trans-surgical depth ≤4mm

3. antibiotic treatment administered during the last 6 months -