Randomised Controlled Trial Assessing the Impact of Genital Herpes Suppressive Therapy on HIV Shedding

• Status: Completed
• Trial end date: 2005-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

Genital herpes is a long-life sexually transmitted diseases which infects a large proportion of women in Africa. Its clinical symptoms are painful sores on the genitals, which heals after a few days. HIV infection can worsen genital herpes. In turn, it is possible that genital herpes increases the quantity of HIV secreted at the genital level in women infected by the 2 viruses. This study is dedicated to verify this hypothesis.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: French National Agency for Research on AIDS and Viral Hepatitis
• Treatments: Valacyclovir

Criteria

Inclusion Criteria:

• Infection with HIV-1 and HSV-2

• If required to take antiretrovirals according to WHO recommendations, should be on HAART for at least 4 months

• Written informed consent

Exclusion Criteria:

• Pregnancy or willing to be pregnant during the next 6 months

• Breastfeeding

• Renal failure

• Expected non-compliance with follow-up or study treatment