Overview

Ramosetron Versus Ondansetron for Radiotherapy Induced Nausea and Vomiting

Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is: 1. To compare prophylactic effect of ondansetron versus ramosetron on radiotherapy induced nausea and vomiting in the treatment of gastrointestinal cancer. 2. To verify an improvement of 20% in complete response rate in term of radiotherapy induced nausea and vomiting (from 60% with ondansetron to 80% with ramosetron).
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Seoul National University Hospital
Treatments:
Ondansetron
Ramosetron
Criteria
Inclusion Criteria:

- AJCC 1-3 staged gastrointestinal cancer patient

- patient undergoing radiotherapy as treatment

- age 20 yr and higher

- ECOG 0-2

Exclusion Criteria:

- age < 20

- ECOG 3-4

- patient experiencing nausea or vomiting prior to accrual

- patient under antiemetic medication

- patient under steroid medication (topical or inhalant steroid application are
exceptional)

- patient under opioid medication