Ramelteon for Complex Insomnia in Veterans With PTSD
Status:
Withdrawn
Trial end date:
2020-06-30
Target enrollment:
Participant gender:
Summary
Obstructive sleep apnea is commonly reported in Veterans with post-traumatic stress disorder,
which can potentiate symptoms of anxiety and depression, daytime symptoms and worsen
nightmares. Continuous positive airway pressure is the most effective therapy but adherence
to treatment is suboptimal. The overarching theme of the proposal is to compare usual care to
Ramelteon, in a randomized, clinical trial, investigating the effectiveness of physiological
versus pharmacological intervention on sleep quality of life, insomnia severity and CPAP
adherence.