Radiotherapy With Cisplatin Versus Radiotherapy With Cetuximab After Induction Chemotherapy for Larynx Preservation
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Larynx preservation remains a very challenging approach in patients with larynx/pharynx
cancer. A first attempt consisted of induction chemotherapy followed in good responders by
irradiation. This approach allowed to preserve 60 % of the larynx without any significant
difference in survival. The second attempt consisted of concurrent chemo-irradiation. This
approach provided a higher larynx preservation rate but survival remained unchanged and
mucosal toxicity was also higher. A third approach is currently under evaluation: induction
chemotherapy followed by concurrent chemo-irradiation in good responders.
Phase:
Phase 2
Details
Lead Sponsor:
Groupe Oncologie Radiotherapie Tete et Cou
Collaborators:
Groupe d'Etude des Tumeurs de la Tête Et du Cou Tumor Study Group Head and Neck