Radiotherapy + Metronidazole vs Radiotherapy Alone In Improving Treatment Outcomes in Advanced Cervical Cancer in Uganda

• Status: Completed
• Trial end date: 2010-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

The objective of the study was to determine whether there was a difference in the effectiveness of Radiotherapy alone compared with Radiotherapy plus Metronidazole in the treatment of women with advanced cancer of the cervix in Mulago hospital. It was a randomized controlled trial composed of 38 women altogether, with one group composed of randomly selected women with advanced cancer of the cervix treated with radiotherapy alone and the other group composed of similar women but treated with radiotherapy and metronidazole.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Makerere University
• Treatments: Metronidazole

Criteria

Inclusion Criteria:

• Women with cancer of the cervix who had histologically proven stage IIB to IVB cancer of the cervix.

• Women with cancer of the cervix who had been assessed and found fit for radiotherapy

• Women with cancer of the cervix who had Hb 12g/dl and below.

Exclusion Criteria:

• Women who were already on metronidazole treatment for other reasons other than radio sensitization

• Women who had a history of neuropathy